Chromatin roadblocks to reprogramming 50 years on
نویسندگان
چکیده
منابع مشابه
Reprogramming Roadblocks Are System Dependent
Since the first generation of induced pluripotent stem cells (iPSCs), several reprogramming systems have been used to study its molecular mechanisms. However, the system of choice largely affects the reprogramming efficiency, influencing our view on the mechanisms. Here, we demonstrate that reprogramming triggered by less efficient polycistronic reprogramming cassettes not only highlights mesen...
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The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin structure and function. The complex interrelation...
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ژورنال
عنوان ژورنال: BMC Biology
سال: 2012
ISSN: 1741-7007
DOI: 10.1186/1741-7007-10-83